Pregnancy and Coronavirus Disease 19
PDF

Keywords

COVID19
Pregnancy
Newborn
Prenatal care
Breast milk

Categories

How to Cite

1.
Shankar M, KR N. Pregnancy and Coronavirus Disease 19. Integr J Med Sci [Internet]. 2020 Aug. 4 [cited 2024 Nov. 21];7. Available from: https://mbmjpress.com/index.php/ijms/article/view/195

Abstract

Coronavirus disease 2019 (COVID 19) is declared a global pandemic. Management of expecting mothers and newborn care becomes a great challenge to the physicians and their families. They should follow the same guidelines as the general population to avoid exposure to the virus as much as possible. Pregnancy does not seem to increase the risk of infection nor accelerate its natural history or the severity of illness. Routine prenatal-antenatal care should be home monitored and telemedicine encouraged as much as possible. Women with comorbidities or at high risk of infection such as a recent history of travel, from a containment zone, history of primary or secondary contact should be closely monitored for symptoms. RT PCR is recommended before labor or one day before elective surgery. Supportive treatment is important in infected patients. Low molecular weight heparin can be used for thromboprophylaxis in severe illnesses. Data on the use of Remdesivir, hydroxychloroquine, Lopinavir-Ritonavir are limited. There is limited data on the placental transmission of the virus. The newborn should also be immediately be tested following the delivery of a COVID19 pregnant woman. If the newborn is found to be negative, strict hygienic measures according to CDC should be followed to express breast milk. According to WHO, breast milk banks are a safe alternative. Few mothers may prefer to give formula feeds, which can be administered by healthy caregivers. There is limited data regarding the transmission of the virus through breast milk.

https://doi.org/10.15342/ijms.7.195
PDF

References

United States Centers for Disease Control and Prevention. Coronavirus disease 2019 (COVID-19). Caring for children.Georgia.2020. [Accessed 2020 May 31]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/daily-life-coping/children.html

American College of Obstetricians and Gynecologists. COVID-19 FAQs for obstetricians-gynecologists, obstetrics. Washington, DC: ACOG; 2020. [Accessed 2020 Jun 01]. Available From: https://www.acog.org/clinical-information/physician-faqs/covid-19-faqs-for-ob-gyns-obstetrics

Royal College of Obstetricians and Gynecologists. COVID-19 virus infection and pregnancy. Occupational health advice for employers and pregnant women during the COVID-19 pandemic. United Kingdom. 2020. [Accessed 2020 May 31]. Available from: https://www.rcog.org.uk/en/guidelines-research-services/guidelines/coronavirus-pregnancy/covid-19-virus-infection-and-pregnancy

Stokes EK, Zambrano LD, Anderson KN, Marder EP, Raz KM, El Burai Felix S, Coronavirus Disease 2019 Case Surveillance — United States, January 22–May 30, 2020. MMWR Morb Mortal Wkly Rep. 2020 Jun 19; 69(24):759-765. https://doi.org/10.15585/mmwr.mm6924e2

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020 Mar 17;323(11):1061–9. https://doi.org/10.1001/jama.2020.1585

Danzi GB, Loffi M, Galeazzi G, Gherbesi E. Acute pulmonary embolism and COVID-19 pneumonia: a random association? Eur Heart J. 2020 May 14;41(19):1858. https://doi.org/10.1093/eurheartj/ehaa254

Breslin N, Baptiste C, Miller R, Fuchs K, Goffman D, Gyamfi-Bannerman C, et al. Coronavirus disease 2019 in pregnancy: early lessons. Am J Obstet Gynecol MFM. 2020 May; 2(2):100111. https://doi.org/10.1016/j.ajogmf.2020.100111

Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020 Apr 7;323(13):1239-1242. https://doi.org/10.1001/jama.2020.2648

Huntley BJF, Huntley ES, Di Mascio D, Chen T, Berghella V, Chauhan SP. Rates of Maternal and Perinatal Mortality and Vertical Transmission in Pregnancies Complicated by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Co-V-2) Infection: A Systematic Review. Obstet Gynecol. 2020 Aug;136(2):303-312. https://doi.org/10.1097/aog.0000000000004010

Juan J, Gil MM, Rong Z, Zhang Y, Yang H, Poon LC. Effects of coronavirus disease 2019 (COVID-19) on maternal, perinatal and neonatal outcomes: a systematic review. Ultrasound Obstet Gynecol. 2020 Jul; 56(1):15-27. https://doi.org/10.1002/uog.22088

Breslin N, Baptiste C, Gyamfi-Bannerman C, Miller R, Martinez R, Bernstein K et al. COVID-19 infection among asymptomatic and symptomatic pregnant women: Two weeks of confirmed presentations to an affiliated pair of New York City hospitals. Am J Obstet Gynecol MFM. 2020 May;2(2):100118. https://doi.org/10.1016/j.ajogmf.2020.100118

World Health Organisation Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19).Geneva.16-24 February 2020. [Accessed 2020 Jun 14]. Available from: https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf

Yan J, Guo J, Fan C, Juan J, Yu X, Li J, et al. Coronavirus disease 2019 in pregnant women: a report based on 116 cases. Am J Obstet Gynecol. 2020 Jul; 223(1):111.e1-111.e14. https://doi.org/10.1016/j.ajog.2020.04.014

Wang W, Xu Y, Gao R, Lu R, Han K, Wu G, et al. Detection of SARS-CoV-2 in Different Types of Clinical Specimens. JAMA. 2020 May 12; 323(18):1843-1844. https://doi.org/10.1001/jama.2020.3786

Dong L, Tian J, He S, Zhu C, Wang J, Liu C, et al. Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA. 2020 May 12;323(18):1846-1848. https://doi.org/10.1001/jama.2020.4621

Fang FC, Naccache SN, Greninger AL. The Laboratory Diagnosis of COVID-19-- Frequently-Asked Questions. Clin Infect Dis. 2020 Dec 31;71(11):2996-3001.https://doi.org/10.1093/cid/ciaa742

Bryant JE, Azman AS, Ferrari MJ, Arnold BF, Boni MF, Boum Y, et al. Serology for SARS-CoV-2: Apprehensions, Opportunities, and the Path Forward. Sci Immunol. 2020 May 19;5(47):eabc6347. https://doi.org/10.1126/sciimmunol.abc6347

US Food and Drug Administration. Emergency Use Authorizations.Maryland.2020. [Accessed 2020 Jun16]. Available from: https://www.fda.gov/medical-devices/emergency-situations-medical-devices/emergency-use-authorizations

Centers for Disease Control and Prevention. Interim Guidelines for COVID-19 Antibody Testing in Clinical and Public Health Settings. Georgia. 2020. [Accessed 2020 May 26]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/lab/resources/antibody-tests-guidelines.html?deliveryName=USCDC_2067-DM29085

Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020 Apr; 18(4):844-847. https://doi.org/10.1111/jth.14768

Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar; 30(3):269-271. https://doi.org/10.1038/s41422-020-0282-0

Mulangu S, Dodd LE, Davey RT Jr, Tshiani Mbaya O, Proschan M, Mukadi D, et al; PALM Consortium Study Team. A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics. N Engl J Med. 2019 Dec 12; 381(24):2293-2303. https://doi.org/10.1056/nejmoa1910993

Lacroix I, Bénévent J, Damase-Michel C. Chloroquine and hydroxychloroquine during pregnancy: What do we know? Therapie. Jul-Aug 2020; 75(4):384-385. https://doi.org/10.1016/j.therap.2020.05.004

Wu Y, Liu C, Dong L, Zhang C, Chen Y, Liu J, et al. Coronavirus disease 2019 among pregnant Chinese women: case series data on the safety of vaginal birth and breastfeeding. BJOG. 2020 Aug; 127(9):1109-1115. https://doi.org/10.1111/1471-0528.16276

Liu W, Wang J, Li W, Zhou Z, Liu S, Rong Z. Clinical characteristics of 19 neonates born to mothers with COVID-19. Front Med. 2020 Apr; 14(2):193-198. https://doi.org/10.1007/s11684-020-0772-y

Centers for Disease Control and Prevention. Interim Considerations for Infection Prevention and Control of Coronavirus Disease 2019 (COVID-19) in Inpatient Obstetric Healthcare Settings.Georgia.2020. [Accessed 2020 Apr 09].Available from: https://www.cdc.gov/coronavirus/2019-ncov/hcp/inpatient-obstetric-healthcare-guidance.html

Quigley M, McGuire W. Formula versus donor breast milk for feeding preterm or low birth weight infants. Cochrane Database Syst Rev. 2014 Apr 22;(4):CD002971. https://doi.org/10.1002/14651858.cd002971.pub3

WHO. Donor human milk for low-birth-weight infants. Geneva. 2019. [Accessed 2020 Apr 30] Available from: https://www.who.int/elena/titles/donormilk_infants/en/

Natalie Shenker. Maintaining safety and service provision in human milk banking: a call to action in response to the COVID-19 pandemic. Lancet Child Adolesc Health. 2020 Jul;4(7):484-485. https://doi.org/10.1016/s2352-4642(20)30134-6

American academy of pediatrics. Breastfeeding Guidance Post Hospital Discharge for Mothers or Infants with Suspected or Confirmed SARS-CoV-2 Infection. Itasca, IL USA. 2020. [Accessed 2020 Jun 20]. Available from: https://services.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/breastfeeding-guidance-post-hospital-discharge/

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2020 Mythri Shankar and Nishanth KR

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...