Keywords
Men
Leiomyosarcoma
Immunohistochimy
Surgery
Radiotherapy
Categories
How to Cite
Abstract
Primary Sarcomas of the breast account for less than 1% of breast tumors. Leiomyosarcomas are less common. Only 51 cases have been reported in the literature, which only 4 cases in men. We present a new case of male breast leiomyosarcoma and discuss the management and therapy of these unusual neoplasms. The confirmation of diagnosis was obtained by immunohistochemical study of surgical biopsy. The patient underwent a radical mastectomy and axillary lymphadenectomy. Adjuvant radiotherapy was indicated. Two years after surgery the patient is still in life without recurrence.
References
Markaki S, Sortiropoulou M, Hanioti C, Lazaris D. Leiomyosarcoma of the breast: A clinicopathologic and immunohistochemical study. Eur J Obstet Gynecol Reprod Biol. 2003 Feb 10; 106(2): 233-6. https://doi.org/10.1016/s0301-2115(02)00226-9
Munitiz V, Rios A, Canovasa J, Ferri B, Sola J, Canovas P, et al. Primitive leiomyosarcoma of the breast: case report and review of the literature. Breast. 2004; 13(1): 72-6. https://doi.org/10.1016/j.breast.2003.09.004
Agrawal P , Garg N, Pandey BB. Primary leiomyosarcoma of breast: A rare case-report. Arch Breast Cancer [Internet]. 2015 Aug; 2(3): 31. [Accessed 2021 Jun 25]. Available from: https://archbreastcancer.com/index.php/abc/article/view/44
Adem C, Reynolds C, Ingle JN, Nascimento AG. Primary breast sarcoma: clinic-pathologic series from the Mayo Clinic and review of the literature. Br J Cancer. 2004 Jul 19; 91(2): 237–241. https://doi.org/10.1038/sj.bjc.6601920
Rane SU, Batra C, Saikia UN. Primary Leiomyosarcoma of Breast in an Adolescent Girl: A Case Report and Review of the Literature. Case Rep Pathol. 2012; 2012:491984. https://doi.org/10.1155/2012/491984
Fujita N, Kimura R, Yamamura J, Akazawa K, Kasugai T, Tsukamoto F. Leiomyosarcoma of the breast: A case report and review of the literature about therapeutic management. Breast. 2011 Oct; 20(5): 389-93. https://doi.org/10.1016/j.breast.2011.03.001
Amaadour L, Benbrahim Z, Moumna K, Boudahna L, Amarti A, Arifi S, et al. Primary Breast Leiomyosarcoma. Case Rep Oncol Med. 2013; 2013: 732730. https://doi.org/10.1155/2013/732730
Lee SY, Lee NR. Positive response of a primary leiomyosarcoma of the breast following salvage hyperthermia and pazopanib. Korean J Intern Med. 2018 Mar;33(2)442-445. https://doi.org/10.3904/kjim.2015.242
Masannat Y, Sumrien H, Sharaiha Y. Primary Leiomyosarcoma of the Male Breast: A Case Report. Case Rep Med. 2010; 2010: 534102. https://doi.org/10.1155/2010/534102
Kim BR, Lee JH, Cho E, Kim DC, Park YM, Ha DH, et al. Primary Breast Leiomyosarcoma located in the Premammary zone: A case Report. ClinImaging. Nov-Dec 2015; 39(6):1105-7. https://doi.org/10.1016/j.clinimag.2015.06.014
Hussien M, Sivananthan S, Anderson N, Shiels A, Tracey N, Odling-Smee GW. Primary leiomyosarcoma of the breast: diagnosis, management and outcome. A report of a new case and review of literature. Breast. 2001 Dec;10(6):530-4. https://doi.org/10.1054/brst.2000.0276
Chen KT, Kuo TT, Hoffmann KD. Leiomyosarcoma of the breast: a case of long survival and late hepatic metastasis. Cancer. 1981 Apr 1;47(7): 1883-6. https://doi.org/10.1002/1097-0142(19810401)47:7%3C1883::aid-cncr2820470728%3E3.0.co;2-t
Stafyla VK, Gauvin JM, Farley DR. A 53-year-old woman with a leiomyosarcoma of the breast. Curr Surg. Nov-Dec 2004; 61(6): 572-5. https://doi.org/10.1016/j.cursur.2004.05.008
Nielsen BB. Leiomyosarcoma of the breast with late dissemination. Virchows Arch A Pathol Anat Histopathol. 1984; 403(3): 241-5. https://doi.org/10.1007/bf00694900
Parham DM, Robertson AJ, Hussein KA, Davidson AI. Leiomyosarcoma of the breast: cytological and histological features, with a review of the literature. Cytopathology. 1992; 3(4): 245-252. https://doi.org/10.1111/j.1365-2303.1992.tb00514.x
Wei CH, Wan CY, Chen A. Epithelioid leiomyosarcoma of the breast: report of a case. J Formos Med Assoc 1993; Apr 92(4):379-81.
Jayaram G, Jayalakshmi P, Yip CH. Leiomyosarcoma of the breast: report of a case with fine needle aspiration cytologic, histologic and immunohistochemical features. Acta Cytol. 2005; 49(6):656-60. https://doi.org/10.1159/000326256
Vu LT, Luce J, Knudson MM. Image of the month: leiomyosarcoma of the breast. Arch Surg. 2006 Dec;141(12):1263-4. https://doi.org/10.1001/archsurg.141.12.1263
Bassett P, Shaban J, Fulger I. Twenty-year-old female with leiomyosarcoma of the breast. J Surg Case Rep. 2014 Jan 10; 2014(1):rjt121. https://doi.org/10.1093/jscr/rjt121
Van der Graaf WT, Blay JY, Chawla SP, Kim DW, Bui-Nguyen B, Bui-Nguyen B, et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet 2012 May 19; 379(9829):1879-86. https://doi.org/10.1016/s0140-6736(12)60651-5
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