The Central Giant Cell Granuloma of the Mandible: A Case Report
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Keywords

giant cells / granuloma / Treatment / hyperparathyroidism

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1.
Azzouzi A, El Harti K. The Central Giant Cell Granuloma of the Mandible: A Case Report. Integr J Med Sci [Internet]. 2021 Nov. 9 [cited 2024 Nov. 21];8. Available from: https://mbmjpress.com/index.php/ijms/article/view/477

Abstract

The Giant central cell granuloma (GCCG) is a benign intra-osseous lesion of the neo-plastic type. It appears mainly in the mandible, but can be observed in the maxilla and small bones of the hand and foot, with a predilection for the female sex and prevalence at a young age. Its diagnosis is clinical and radiological, confirmed by histological examination. The differential diagnosis is biological because it has a wide range of morphologies and a misinterpretation with other giant cell lesions can often occur. The authors present a case of the Giant central cell granuloma in a 62-year-old woman developing for 3 years after dental extractions. The most favorable treatment for giant cell granulomas is surgical whose main objective is to prevent recurrences.

https://doi.org/10.15342/ijms.2021.477
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References

Jaffe HL. Giant-cell reparative granuloma, traumatic bone cyst,and fibrous (fibro-osseous) dysplasia of the jawbones. Oral Surg Oral Med Oral Pathol. 1953 Jan; 6(1):159-175. https://doi.org/10.1016/0030-4220(53)90151-0

de Lange J, van den Akker HP, van den Berg H. Central giant cell granuloma of the jaw: a review of the literature with emphasis on therapy options. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Nov; 104(5): 603-615. https://doi.org/10.1016/j.tripleo.2007.04.003

Barthélémy I, Mondié JM. Tumeurs et pseudotumeurs des maxillaires riches en cellules géantes. Rev Stomatol Chir Maxillofac. 2009 Sep; 110(4):209-13. https://doi.org/10.1016/j.stomax.2009.06.002

Valentine JC, Nelson BL. Central giant cell lesion. Head Neck Pathol. 2011 Dec; 5(4):385-8. https://doi.org/10.1007/s12105-011-0297-4

Sioud S, Bertolus C, Gruffaz F, Ghoul S, Menard P, Bertrand JC, et al. Tumeurs à cellules géantes: à propos de trois cas récidivants chez des sujets jeunes. Rev Stomatol Chir Maxillofac. 2007 Apr; 108(2): 131-134. https://doi.org/10.1016/j.stomax.2005.12.005

Jerkins D, Malotky M, Miremadi R, Dole M. Central Giant Cell Granuloma of the Mandible Requiring Multiple Treatment Modalities – A Case Report. J Oral Maxillofac Surg. 2016 Aug; 74(8): 1596-607. https://doi.org/10.1016/j.joms.2016.02.019

Amaral FR, Gomes CC, Oliveira CS, Souza PEAD, Gomez RS. Clonality analysis of giant cell lesions of the jaws. Braz Dental J. 2010; 21(4):361-4. https://doi.org/10.1590/s0103-64402010000400013

Chawla C, Rao PK, Kini R, Bhandarkar GP, Kashyap R, Holla V. Central giant cell granuloma-a case report. Am J Diagn Imaging. 2017; 2: 17-20. https://doi.org/10.5455/AJDI.20161219105205

Barnes L, Eveson JW, Reichart P, Sidransky D, editors. World health organization classification of tumours: head and neck tumors. IARC Press: Lyon; 2005. [Accessed 2021 Nov 11]. Available from: https://screening.iarc.fr/doc/BB9.pdf

Borges HO, Machado RA, Vidor MM, Beltrao RG, Heitz C, Filho MS. Calcitonin: a non-invasive giant cells therapy. Int J Pediatr Otorhinolaryngol. 2008 Jul; 72(7): 959-963. https://doi.org/10.1016/j.ijporl.2008.03.016

Tosco P, Tanteri G, Iaquinta C, Fasolis M, Roccia F, Berrone S, et al. Surgical treatment and reconstruction for central giant cell granuloma of the jaws: a review of 18 cases. J Craniomaxillofac Surg. 2009 Oct; 37(7): 380-7. https://doi.org/10.1016/j.jcms.2009.04.002

de Oliveira JP, Olivete F, de Oliveira ND, Giovanini AF, Zielak JC, Klüppel L, et al. Combination therapies for the treatment of recurrent central giant cell lesion in the maxilla: a case report. J Med Case Rep. 2017 Mar 20; 11(1):74. https://doi.org/10.1186/s13256-016-1173-3

Whitaker SB, Waldron CA. Central giant cell lesions of the jaws. A clinical, radiologic, and histopathologic study. Oral Surg Oral Med Oral Pathol 1993 Feb; 75(2):199-208. https://doi.org/10.1016/0030-4220(93)90094-k

Garg P, Jain J, De N, Chatterjee K. A central giant cell granuloma in posterior part of maxilla—A case report. Int J Surg Case Rep. 2017; 30:222–225. https://doi.org/10.1016/j.ijscr.2016.11.015

Barthélémy I, Mondié JM. Tumeurs et pseudotumeurs des maxillaires riches en cellules géantes. Rev Stomatol Chir MaxilloFac. 2009 Sep; 110(4): 209-13. https://doi.org/10.1016/j.stomax.2009.06.002

da Silva NG, Carreira AS, Pedreira EN, Tuji FM, Ortega KL, de Jesus Viana Pinheiro J. Treatment of central giant cell lesions using bisphosphonates within traditional corticosteroid injections. Head Face Med. 2012 Aug 22; 8:23. https://doi.org/10.1186/1746-160x-8-23

dos Santos B, Koth VS, Figueiredo MA, Salum FG, Cherubini K. Brown tumor of the jaws as a manifestation of tertiary hyperparathyroidism: A literature review and case report. Special Care in Dentistry 2018; 38(3): 163-171. https://doi.org/10.1111/scd.12284

Al Sheddi MA, Mosadomi HA, Al Dayel FH. Central giant cell granuloma of the jaws and giant cell tumor of long bones: A clinicopathological, cytometric and immunohistochemical comparative study. Saudi J Oral Sci. 2014; 1(1):47-53. https://doi.org/10.4103/WKMP-0056.124190

McArthur D, Palacios E, Nguyen J. Maxillary Giant Cell Granuloma: A Long-Term Follow-Up. Ear Nose Throat J. 2019 Jul; 98(6): E70–E72. https://doi.org/10.1177/0145561319841238

Guerrissi JO. Giant cells mandibular lesion: surgical treatment with preservation of the dentition. J Craniofac Surg. 2013 Jul; 24(4):1394-6. https://doi.org/10.1097/scs.0b013e31829501d3

Eisenbud L, Stern M, Rothberg M, Sachs SA. Central giant cell granuloma of the jaws: experiences in the management of thirty-seven cases. J Oral Maxillofac Surg. 1988 May; 46: 376–84. https://doi.org/10.1016/0278-2391(88)90221-2

Kurtz M, Mesa M, Alberto P. Treatment of a central giant cell lesion of the mandible with intralesional glucocorticosteroids. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Jun; 91(6): 636-7. https://doi.org/10.1067/moe.2001.115721

Nogueira RLM, Teixeira RC, Cavalcante RB, Ribeiro RA, Rabenhosrt SHB. Intralesional injection of triamcinolone hexacetonide as an alternative treatment for central giant-cell granuloma in 21 cases. Int J Oral Maxillofac Surg. 2010 Dec; 39(12):1204-10. https://doi.org/10.1016/j.ijom.2010.06.015

Schreuder WH, van den Berg H, Westermann AM, Peacock ZS, de Lange J. Pharmacological and surgical therapy for the central giant cell granuloma: a long-term retrospective cohort study. J Cranio maxillo fac Surg. 2017 Feb; 45(2): 232–43. https://doi.org/10.1016/j.jcms.2016.11.011

Rytkönen E, Ottavainen V, Rytkönen A, Uusitalo S, Lehenkari P, Sándor GK. Denosumab treatment for aggressive multiple recurrent familial central giant-cell granulomas. Ann Maxillofac Surg. Jul-Dec 2018; 8(2):265-269. https://doi.org/10.4103/ams.ams_192_18

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Copyright (c) 2021 Asma Azzouzi & Karima El Harti

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